Earthquake was called The Head of Catastrophe in many countries because of its sudden, wide-ranging, and severe loss characteristics. Due to the density of people, economy and buildings in cities, the development and evolution of the earthquake disaster chain presents more complex and varied systemic features. There have been many studies of seismic scenarios, most of which focus on the simulation of the disaster itself, but little attention has been paid to the disaster mechanism and its control methods within the urban system. In the view of urban systemic characteristics, this paper analyzes the evolution and development of earthquake disaster scenarios in urban systems. Based on the interaction of various elements of the urban system, the content system of urban seismic scenario research is clarified. Finally, considering the dual scenarios of disaster and response, an urban seismic scenario construction method is proposed which covers risk assessment, disaster simulation, task and capability matching, emergency preparedness plan. We hope that this research can develop the urban earthquake scenario research and provide reference for the earthquake disaster reduction.