Statutory infectious diseases have the characteristics of fast spread, serious illness and high mortality. If the epidemic situation is not controlled timely, it will threaten the safety of life and cause serious social influence, resulting in public health and social security events. This paper will conduct an analysis about the morbidity and mortality of statutory infectious diseases in Zhengzhou, China from 2014 to 2019. Based on the descriptive statistics, correlation and cluster analysis of various diseases, we investigated the distribution of occurrence time of all kinds of statutory infectious diseases and the relationship between various infectious diseases. The study found that the occurrence of infectious diseases has a certain seasonal characteristic, and infectious diseases with similar transmission routes have the same high incidence trend. Finally, effective suggestions on prevention and control of statutory infectious diseases are put forward according to the conclusion of the study.